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Fig. 4 | Biological Research

Fig. 4

From: Short-term perinatal oxygen exposure may impair lung development in adult mice

Fig. 4

Elastin Staining & Lung Morphology. Lungs were assessed by elastin staining in all groups at four weeks (a 21%O2, b 40%O2 & c 100%O2) and 12 weeks (d 21%O2, e 40%O2 & f 100%O2) of age following neonatal oxygen exposure (Scale bar: 100 µm). Alveolar number (g), alveolar surface area per high power field (HPF) (850 × 450 µm; 382,000 µm2) (h), septal length (i), and septal count (j) were assessed at 200 × resolution. There was no difference in alveolar number, alveolar surface area, and septal count among the three oxygen groups at both time points. Septal length demonstrated a significant interaction among the three oxygen groups over time (p < 0.01, Two-way ANOVA). On multiple comparisons, exposure to 100%O2 soon after birth resulted in a significant reduction in the length of the secondary septae at 12 weeks of age in adult mice (*p < 0.01 vs. 21%O2 & 40%O2 groups, Two-way ANOVA). (n = 6/group, each time-point)

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