Fig. 3

MATR3 promotes apoptotic cell death gauged by PARP cleavage. MDA-MB-231 (a introduced with empty vector or MATR3-overexpression vector) and BT549 cells (b introduced with non-silencing control or sh-MATR3) were treated with 0.5% DMSO (−) or 0.5 μM Staurosporine (+) for 24 h and subjected to western blotting. Cleaved PARP (cPARP) was detected with a specific antibody. The lower panels demonstrate the quantitation of the relative normalized cPARP protein levels