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Table 2 The role of some lncRNAs in osteoporosis and their mechanisms through osteoblasts and osteoclasts and targets

From: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

LncRNA ID Target molecule and pathway Effects on osteoblasts differentiation
lncRNA HIF1A-AS1 [46] SIRT1 Promote osteoblast differentiation
LncRNA HoxA-AS3 [47] EZH2, H3K27me3, Runx2 Promote osteoblast differentiation
lncRNA MALAT1 [102] miR-143, miR-204 Promote osteoblast differentiation
lncRNA MODR [103] miR-454 Promote osteoblast differentiation
LncRNA KCNQ1OT1 [104] miR-214 Promote osteoblast differentiation
LncRNA NTF3-5 [105] miR-93-3p Promote osteoblast differentiation
LncRNA POIR [106] miR-182 Promote osteoblast differentiation
LncRNA Linc-ROR [107] miR-145 Promote osteoblast differentiation
LncRNA H19 [100, 101] miR-675, miR-141, miR-22 Promote osteoblast differentiation
LncRNA H19 [53] Wnt/β-catenin pathway, Inhibit osteoblast differentiation
LncRNA-DANCR [48, 49] EZH2, H3K27me3, Runx2, p38 MAPK Inhibit osteoblast differentiation
LncRNA ANCR [50] Wnt/β-catenin pathway Inhibit osteoblast differentiation
LncRNA HOTAIR [51] Wnt/β-catenin pathway Inhibit osteoblast differentiation
lncRNA p21 [52] E2, Wnt/β-catenin pathway Inhibit osteoblast differentiation
Lnc-AK045490 [54] β-catenin, TCF1, LEF1 and Runx2 Inhibit osteoblast differentiation
Lnc-AK016739 [55] osteoblastic TF Inhibit osteoblast differentiation
lncRNA UCA1 [56] BMP-2/(Smad1//5/8) Inhibit osteoblast differentiation
LncRNA MEG3 [57, 58] Wnt/β-catenin signaling pathway Promote osteoblast differentiation
IGF1 Inhibit osteoblast differentiation
LncRNA HOTAIR [108] miR-17-5p, SMAD7 Inhibit osteoblast differentiation
LncRNA MIAT [109] miR-150-5p Inhibit osteoblast differentiation
lncRNA-ORLNC1 [111] miR-296 Inhibit osteoblast differentiation
LncRNA MEG3 [112] miR-133a-3p Inhibit osteoblast differentiation
LncRNA TSIX [52] miR-30a-5p, and Runx2 Promote osteoblast apoptosis
lncRNA TUG1 [86] PTEN Promote osteoclast differentiation
lncRNA AK077216 [87] NIP45, NFATc1 Promote osteoclast differentiation
lncRNA SNHG15 [88] RANK/RANKL pathyway Promote osteoclast differentiation
LncRNA-Jak3 [89] Nfatc1, Ctsk Promote osteoclast differentiation
LncRNA LINC00311 [90] DDL3 Promote osteoclast differentiation
LncRNA RP11-498C9.17 [91] HDAC4 Inhibit osteoclast differentiation
LncRNA Bmncr [92] RANK Inhibit osteoclast differentiation
LncRNA NONMMUT037835.2 [93] RANK, NF-κB/MAPK signaling pathway Inhibit osteoclast differentiation
LncRNA-NEF [94] IL-6 Inhibit osteoclast differentiation