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Table 1 The role of some miRNAs in osteoporosis and their mechanisms through osteoblasts and osteoclasts and targets

From: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

miRNA ID

Target molecule and pathway

Mechanisms that affect osteoporosis through osteoblasts and osteoclasts

miR-33-5p [20]

Hmga2

Promote osteoblast differentiation

miR-194 [22]

Runx2

Promote osteoblast differentiation

miRNA-433-3p [23]

DKK1

Promote osteoblast differentiation

miR-96 [24, 26]

EGFR, HB-EGF

Promote osteoblast differentiation

Promote osteoblast differentiation

Wnt/β-catenin signaling pathway

miR-139-5p [27]

NOTCH1,Wnt/β-catenin pathway

Promote osteoblast differentiation

miR-216a [28]

PI3K/AKT pathway

Promote osteoblast differentiation

Promote osteoblast differentiation

BMP/TGF-β signaling pathway,

miR-124 [39,40,41]

GSK-3β, Wnt/β-catenin pathway

Inhibit osteoblast differentiation

Inhibit osteoblast differentiation

Dlx3, Dlx5, and Dlx2

miR-542-3p [42, 43]

SFRP1

Promote osteoblast differentiation

BMP-7/PI3K- survivin signaling

Inhibit osteoblast differentiation

Inhibit osteoblast differentiation

NKIRAS2, NF-κB signaling

miR-125b [29,30,31]

BMPR1b

Inhibit osteoblast differentiation

miR-375 [32]

Runx2

Inhibit osteoblast differentiation

miR-100 [34]

Smad1

Inhibit osteoblast differentiation

miR-203a-3p [35]

Smad9, Wnt/β-catenin signaling pathway

Inhibit osteoblast differentiation

miR-214-3p [35, 37]

ATF4

Inhibit osteoblast differentiation

miR-153 [38]

BMPP2

Inhibit osteoblast differentiation

miR-21 [69, 70]

RANKL, PI3K/Akt signaling pathway, PDCD4

Promote osteoclast differentiation

miR-183 [71]

RANKL, HO-1

Promote osteoclast differentiation

miR-155 [72, 73]

TNF-α, IL-1β, RANKL, M-CSF, RANK, TRAP, Bcl-2, LEPR, AMPK, p-AMPK, OPG, Bax, TAB 1

Promote osteoclast differentiation

miR-223 [74]

TWIST and Runx2

Promote osteoclast differentiation

miR-19a [74]

TWIST and Runx2

Promote osteoclast differentiation

miR-214 [75]

Pten, PI3K/Akt pathway

Promote osteoclast differentiation

miR-182 [76]

Foxo3, Maml1

Promote osteoclast differentiation

miR-26a [77]

CTGF/CCN2

Inhibit osteoclast differentiation

miR-31 [78]

RhoA

Inhibit osteoclast differentiation

miRNA-17 [79]

RANKL

Inhibit osteoclast differentiation

miR-503 [80]

RANK

Inhibit osteoclast differentiation

miR-126-5p [81, 82]

PTHrP and MMP-13

Inhibit osteoclast differentiation

miR-7b [83]

DC-STAMP

Inhibit osteoclast differentiation

miR-141 [84]

Calcr, EphA2

Inhibit osteoclast differentiation