Skip to main content

Table 1 The role of some miRNAs in osteoporosis and their mechanisms through osteoblasts and osteoclasts and targets

From: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

miRNA ID Target molecule and pathway Mechanisms that affect osteoporosis through osteoblasts and osteoclasts
miR-33-5p [20] Hmga2 Promote osteoblast differentiation
miR-194 [22] Runx2 Promote osteoblast differentiation
miRNA-433-3p [23] DKK1 Promote osteoblast differentiation
miR-96 [24, 26] EGFR, HB-EGF Promote osteoblast differentiation
Promote osteoblast differentiation
Wnt/β-catenin signaling pathway
miR-139-5p [27] NOTCH1,Wnt/β-catenin pathway Promote osteoblast differentiation
miR-216a [28] PI3K/AKT pathway Promote osteoblast differentiation
Promote osteoblast differentiation
BMP/TGF-β signaling pathway,
miR-124 [39,40,41] GSK-3β, Wnt/β-catenin pathway Inhibit osteoblast differentiation
Inhibit osteoblast differentiation
Dlx3, Dlx5, and Dlx2
miR-542-3p [42, 43] SFRP1 Promote osteoblast differentiation
BMP-7/PI3K- survivin signaling Inhibit osteoblast differentiation
Inhibit osteoblast differentiation
NKIRAS2, NF-κB signaling
miR-125b [29,30,31] BMPR1b Inhibit osteoblast differentiation
miR-375 [32] Runx2 Inhibit osteoblast differentiation
miR-100 [34] Smad1 Inhibit osteoblast differentiation
miR-203a-3p [35] Smad9, Wnt/β-catenin signaling pathway Inhibit osteoblast differentiation
miR-214-3p [35, 37] ATF4 Inhibit osteoblast differentiation
miR-153 [38] BMPP2 Inhibit osteoblast differentiation
miR-21 [69, 70] RANKL, PI3K/Akt signaling pathway, PDCD4 Promote osteoclast differentiation
miR-183 [71] RANKL, HO-1 Promote osteoclast differentiation
miR-155 [72, 73] TNF-α, IL-1β, RANKL, M-CSF, RANK, TRAP, Bcl-2, LEPR, AMPK, p-AMPK, OPG, Bax, TAB 1 Promote osteoclast differentiation
miR-223 [74] TWIST and Runx2 Promote osteoclast differentiation
miR-19a [74] TWIST and Runx2 Promote osteoclast differentiation
miR-214 [75] Pten, PI3K/Akt pathway Promote osteoclast differentiation
miR-182 [76] Foxo3, Maml1 Promote osteoclast differentiation
miR-26a [77] CTGF/CCN2 Inhibit osteoclast differentiation
miR-31 [78] RhoA Inhibit osteoclast differentiation
miRNA-17 [79] RANKL Inhibit osteoclast differentiation
miR-503 [80] RANK Inhibit osteoclast differentiation
miR-126-5p [81, 82] PTHrP and MMP-13 Inhibit osteoclast differentiation
miR-7b [83] DC-STAMP Inhibit osteoclast differentiation
miR-141 [84] Calcr, EphA2 Inhibit osteoclast differentiation