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Fig.3 | Biological Research

Fig.3

From: REC8 suppresses tumor angiogenesis by inhibition of NF-κB-mediated vascular endothelial growth factor expression in gastric cancer cells

Fig.3

Depletion of REC8 enhanced HUVECs migration and tube formation through upregulation of VEGF in gastric cancer cells. a–c The mRNA and protein level of VEGF were analyzed by real-time qPCR, western blotting and ELISA in BGC823 and AGS-1 cells. ***p < 0.001, **p < 0.01 verus shCTL. d–g Transwell assay and tube formation assay were employed to detect HUVEC migration and tube formation with or without neutralizing VEGF antibody in CM from indicated group in BGC823 cells. Quantification was performed to analyze the statistical significance. ***p < 0.001

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Biological Research

ISSN: 0717-6287

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