Fig. 7

MiR-380-3p reduced the effects of HIF-1α/NLRP3 on inflammation by Circ 0001723. MiR-380-3p expression (a), HIF-1α, NLRP3 and Caspase-1 protein expression by western blot analysis (b–d) and statistical analysis (e), TNF-α (f), IL-1β (g), IL-6 (h) and IL-18 (i). Negative, negative control group; 0001723, over-expression of Circ 0001723 group; 0001723 + miR-380-3p, over-expression of Circ 0001723 and miR-380-3p group **p < 0.01 compared with negative control group, ^##p < 0.01 compared with over-expression of Circ 0001723 group