Fig. 5

MiR-380-3p regulated HIF-1α/NLRP3 in vitro model of SCI. MiR-380-3p expression (a), TNF-α (b), IL-1β (c), IL-6 (d) and IL-18 (e), Heat map for HIF-1α/NLRP3 (f), miR-380-3p target HIF-1α mRNA (g), Luciferase reporter activity (h), HIF-1α, NLRP3 and Caspase-1 protein expression by western blot analysis (i–k) and statistical analysis (l). Negative, negative control group; miR-380-3p, over-expression of miR-380-3p group. **p < 0.01 compared with negative control group