Skip to main content

Table 1 Regulation mechanisms of β-catenin phosphorylation

From: β-Catenin: oncogenic role and therapeutic target in cervical cancer

Subcellular localization Regulators Sites Function Reference(s)
Membrane Fer, Fyn, c-Met Y142 Diminishes α-catenin binding [38]
c-Src,cMet, EGFR Y654 Dissociates the E-cadherin/β-catenin complex [44]
Ab1 Y489 Dissociates the E-cadherin/β-catenin complex [45]
c-Src Y86 Promotes the separation of Y654 and E-cadherins [37]
PKD1 T120 Transports β-catenin to the Golgi apparatus [46]
PT1B Y654 Removes the phosphate group from the phosphorylated Y654 site [47]
Cytoplasm CK1 S45 Embarks β-catenin for β-Trcp recognition [48]
  GSK3β S33, S37, T41 Embarks β-catenin for β-Trcp recognition [48]
Nucleus Fer,Fyn,Yes,and Src T142 Promotes β-catenin binding to the nuclear transporter Bcl9 [38]
  AKT and PKA S552, S675 Strengthens β-catenin/TCF reporter activation [42, 43]
  PKAL S663 Regulates its transcriptional activity and induces target gene expression [49]
  CK1 S45 Sox9 transfers the destruction complex “GSK3β-βTRCP-CK1-Axin” into the nucleus and diminishes nuclear β-catenin [110]
  GSK3β S33, S37, T41 Sox9 transfers the destruction complex “GSK3β-βTRCP-CK1-Axin” into the nucleus and diminishes nuclear β-catenin [110]