From: β-Catenin: oncogenic role and therapeutic target in cervical cancer
Subcellular localization | Regulators | Sites | Function | Reference(s) |
---|---|---|---|---|
Membrane | Fer, Fyn, c-Met | Y142 | Diminishes α-catenin binding | [38] |
c-Src,cMet, EGFR | Y654 | Dissociates the E-cadherin/β-catenin complex | [44] | |
Ab1 | Y489 | Dissociates the E-cadherin/β-catenin complex | [45] | |
c-Src | Y86 | Promotes the separation of Y654 and E-cadherins | [37] | |
PKD1 | T120 | Transports β-catenin to the Golgi apparatus | [46] | |
PT1B | Y654 | Removes the phosphate group from the phosphorylated Y654 site | [47] | |
Cytoplasm | CK1 | S45 | Embarks β-catenin for β-Trcp recognition | [48] |
GSK3β | S33, S37, T41 | Embarks β-catenin for β-Trcp recognition | [48] | |
Nucleus | Fer,Fyn,Yes,and Src | T142 | Promotes β-catenin binding to the nuclear transporter Bcl9 | [38] |
AKT and PKA | S552, S675 | Strengthens β-catenin/TCF reporter activation | ||
PKAL | S663 | Regulates its transcriptional activity and induces target gene expression | [49] | |
CK1 | S45 | Sox9 transfers the destruction complex “GSK3β-βTRCP-CK1-Axin” into the nucleus and diminishes nuclear β-catenin | [110] | |
GSK3β | S33, S37, T41 | Sox9 transfers the destruction complex “GSK3β-βTRCP-CK1-Axin” into the nucleus and diminishes nuclear β-catenin | [110] |