Fig. 3
From: β-Catenin: oncogenic role and therapeutic target in cervical cancer
Wnt/β-catenin signaling pathway. In the absence of the Wnt signal, free cytoplasmic β-catenin is recognized and recruited by the destruction complex, where CK1 and GSK3β phosphorylate it, thereby undergoes ubiquitination-dependent proteolysis. In the presence of Wnt ligands, Wnt signaling blocks the activity of the destruction complex, and subsequently, β-catenin accumulate. Increased levels of cytoplasmic β-catenin translocate into the nucleus, where it associates with DNA binding proteins from the TCF/LEF family and other co-transcription factors. β-Catenin-TCF/LEF transcription complex then drives the transcription of Wnt/β-catenin target genes