Fig. 4

Systemic delivery of EGFP hiPSC-derived myogenic progenitors engrafted in muscles of mdx mice. a Immunofluorescence assays showed no dystrophin and GFP expression was observed in the muscles of negative control mdx mice (upper panel), while the expression of dystrophin (red) and GFP (green) in the intravenously-injected TA muscles (lower panel) was detected after 8 weeks of transplantation. b Quantitative analysis of dystrophin-positive myofibers in the muscles of cell-transplanted and PBS-injected mdx mice. Data are presented as the mean ± SEM (5 random sections for each muscle were examined). ***P < 0.001. Scale bars = 400 μm