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Fig. 3 | Biological Research

Fig. 3

From: Engraftment of human induced pluripotent stem cell-derived myogenic progenitors restores dystrophin in mice with duchenne muscular dystrophy

Fig. 3

Restoration of dystrophin expression in mdx mice after intramuscular transplantation of EGFP hiPSC-derived myogenic progenitors. a Immunofluorescence analysis showed no expression of dystrophin (red) and GFP (green) in TA muscles of negative control mdx mice (upper panels), while dystrophin and GFP double expression in PBS-injected right TA muscles (middle panels) and cell-transplanted left TA muscles (lower panels) at 4 weeks after transplantation. b Immunofluorescence analyses showed dystrophin and GFP double positive myofibers in cell-transplanted left TA muscles at 8 weeks after transplantation. c Immunofluorescence analyses showed dystrophin and GFP double positive myofibers in cell-transplanted left TA muscles at 12 weeks after transplantation. d Quantitative analysis demonstrated the number of dystrophin-positive myofibers for each group at 4, 8, and 12 weeks after transplantation. Data are presented as the mean ± SEM (5 random sections for each muscle were examined). **P < 0.01, ***P < 0.001. Scale bars = 400 μm

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