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Fig. 4 | Biological Research

Fig. 4

From: Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Fig. 4

Upregulation of miR-138-5p promoted DDP-mediated apoptosis in DDP-resistant ovarian cancer cells. a Cell apoptosis in DDP-treated SKOV3/DDP and A2780/DDP cells with miR-138-5p overexpression was determined by annexin V-FITC and PI staining through flow cytometry. b Expression levels of EZH2, SIRT1, Bcl2, Bax, Cl-caspase 3 and Cl-PARP were evaluated by western blot analysis. c Dual-luciferase assay was used to verify the direct binding of miR-138-5p with EZH2 and SIRT1. Data were presented as mean ± SD. * p < 0.05

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