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Fig. 1 | Biological Research

Fig. 1

From: Knockdown of long non-coding RNA HOTAIR reverses cisplatin resistance of ovarian cancer cells through inhibiting miR-138-5p-regulated EZH2 and SIRT1

Fig. 1

Expression levels of HOTAIR and miR-138-5p in DDP-resistant ovarian cancer cells. a The effect of different concentrations of DDP on cell viability in DDP sensitive (SKOV3 and A2780) and DDP resistant (SKOV3/DDP and A2780/DDP) cells was determined by MTT assay, and the IC50 value was obtained. Real-time PCR was employed to evaluate the expression of b HOTAIR and c mir-138-5p in DDP sensitive (SKOV3 and A2780) and DDP resistant (SKOV3/DDP and A2780/DDP) cells, beta-actin and U6 were used as an internal control for HOTAIR and miR-138-5p detection, respectively. Data were presented as mean ± SD. * p < 0.05

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