TY - JOUR AU - Verdugo, Ricardo A. AU - Di Genova, Alex AU - Herrera, Luisa AU - Moraga, Mauricio AU - Acuña, Mónica AU - Berríos, Soledad AU - Llop, Elena AU - Valenzuela, Carlos Y. AU - Bustamante, M. Leonor AU - Digman, Dayhana AU - Symon, Adriana AU - Asenjo, Soledad AU - López, Pamela AU - Blanco, Alejandro AU - Suazo, José AU - Barozet, Emmanuelle AU - Caba, Fresia AU - Villalón, Marcelo AU - Alvarado, Sergio AU - Cáceres, Dante AU - Salgado, Katherine AU - Portales, Pilar AU - Moreno-Estrada, Andrés AU - Gignoux, Christopher R. AU - Sandoval, Karla AU - Bustamante, Carlos D. AU - Eng, Celeste AU - Huntsman, Scott AU - Burchard, Esteban G. AU - Loira, Nicolás AU - Maass, Alejandro AU - Cifuentes, Lucía PY - 2020 DA - 2020/04/16 TI - Development of a small panel of SNPs to infer ancestry in Chileans that distinguishes Aymara and Mapuche components JO - Biological Research SP - 15 VL - 53 IS - 1 AB - Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may be confounded with socio-economic factors due to population stratification. Therefore, ancestry is a potential confounder variable that should be considered in epidemiologic studies and in public health plans. However, there are few studies that have assessed the ancestry of the current admixed Chilean population. This is partly due to the high cost of genome-scale technologies commonly used to estimate ancestry. In this study we have designed a small panel of SNPs to accurately assess ancestry in the largest sampling to date of the Chilean mestizo population (n = 3349) from eight cities. Our panel is also able to distinguish between the two main Amerindian components of Chileans: Aymara from the north and Mapuche from the south. SN - 0717-6287 UR - https://doi.org/10.1186/s40659-020-00284-5 DO - 10.1186/s40659-020-00284-5 ID - Verdugo2020 ER -