Fig. 4

miR-30b-3p reduced the expression of CTHRC1 by targeting its 3′-UTR. a The potential binding site of miR-30b-3p was found in the 3′-UTR (114–121 bp) of CTHRC1 gene. b miR-30b-3p down-regulated luciferase activity of CTHRC1 wild-type 3′-UTR, but it had no effect on the luciferase activity of CTHRC1 mutant-type 3′-UTR. Black up-pointing triangle mean P < 0.05 vs 3′-UTR-wt + mir-30b-3p mimic