Fig. 1

Overexpression of SNHG1 inhibits the viability and promotes the apoptosis in SH-SY5Y cells treated with MPP⁺. a Expression levels of SNHG1 in midbrain of MPTP-induced PD mice. b Expression levels of SNHG1 in SH-SY5Y cells after treatment with 1 mM MPP⁺ for 48 h. c Effects of si-SNHG1 or pcDNA-SNHG1 on the expression level of SNHG1 in SH-SY5Y cells were measured by qRT-PCR. d MTT assay was performed to detect the viability in MPP⁺-treated SH-SY5Y cells after transfection with si-SNHG1 or pcDNA-SNHG1. e Flow cytometry analysis was conducted to examine the effects of SNHG1 overexpression or knockdown on apoptosis in SH-SY5Y cells in the presence of MPP⁺. **P < 0.01