Fig. 6

Graphic abstract for the functional role of resveratrol on adjuvant arthrits. a TG, an inhibitor of the endoplasmic reticulum Ca²⁺-ATPase, prevents the intracellular calcium from flowing into the ER by blocking SERCA, leading to an one-way efflux of calcium from the ER to the cytosol. b ATP binds to the purinergic receptor (P2Y or P2X) on the cell membrane, and then couples with the PLC and activates the IP3 receptor on the ER leading to emptying of the calcium pool, at which time the addition of extracellular calcium induces SOCE. c In the present study, resveratrol reduces TG or ATP induced store-operated Ca²⁺ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1/STIM1 dimer. d Alleviation of tissue injury via resveratrol in AA rats was accompanied with reduced inflammatory level manifested as reduced IL-1, IL-6, IL-8 and TNF-α, and improved hemogram with reduced level of WBC, NEUT, LYMPH, MONO and increased MCV and MCH