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Table 2 Tumor suppressive genes negatively regulated by TFAP2C in NSCLC

From: TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells

Gene Location Mechanism of tumorigenesis Biological activity Reference (PMID)
GADD45B Chromosome 19, NC_000019.10 (2476125..2478259) Activation of MTK1-p38 pathway Cell cycle arrest and apoptosis 12933797
Activation of CDKN1A expression Cell cycle arrest and apoptosis 27572311
Decrease of JNK and STAT5 Apoptosis and anti-proliferation 30279966
PMAIP1 Chromosome 18, NC_000018.10 (59899960..59904306) Decrease of USP9X-MCL1 pathway Apoptosis 24991768
Activation of Beclin-1 via decrease of MCL1 Autophagy and cell death 21353614
Activation of the mitochondrial apoptotic pathway via interaction with BIM Apoptosis 26497683
XAF1 Chromosome 17, NC_000017.11 (6755408..6775647) Activation of Beclin-1 and decrease of Akt pathway Apoptosis, autophagy, and cell death 21788101
Decrease of VEGF Apoptosis, anti-proliferation, and anti-angiogenesis 24980821
IL24 Chromosome 1, NC_000001.11 (206897404..206904139) Activation of eIF2α phosphorylation Apoptosis 28461326
Decrease of Wnt/β-catenin signaling Apoptosis and anti-angiogenesis 23720015
ATF3 Chromosome 1, NC_000001.11 (212565334..212620777) Activation of PMAIP1 Apoptosis 29352505
Activation of Smad signaling Cell death 20930144
CYR61 Chromosome 1, NC_000001.11 (85580761..85583967) Activation of integrin α6-ROS-p38 pathway via activation of p53 Anti-proliferation 26028023
Decrease of MMP-2 Anti-cell motility and anti-invasion 19632997
DLC1 Chromosome 8, NC_000008.11 (13083361..13604616, complement) Decrease of RhoA Anti-angiogenesis 28408355
Decrease of VEGF via EGFR-MEK-HIF pathway Anti-angiogenesis 20861185
TNFAIP3 Chromosome 6, NC_000006.12 (137866317..137883314) Decrease of AKT1/TRIO/RAC1 pathway Inhibition of EMT, anti-migration and anti-invasion 27676292
Decrease of Wnt signaling via interaction with β-catenin destruction complex Apoptosis and anti-angiogenesis 23671587
RHOB Chromosome 2, NC_000002.12 (20447071..20449445) Activation of E-cadherin and decrease of Vimentin Anti-migration and anti-invasion 28253718
Decrease of NF-κB signaling Anti-angiogenesis, anti-migration and anti-invasion 20383180