Table 2 Tumor suppressive genes negatively regulated by TFAP2C in NSCLC
Gene | Location | Mechanism of tumorigenesis | Biological activity | Reference (PMID) |
|---|---|---|---|---|
GADD45B | Chromosome 19, NC_000019.10 (2476125..2478259) | Activation of MTK1-p38 pathway | Cell cycle arrest and apoptosis | 12933797 |
Activation of CDKN1A expression | Cell cycle arrest and apoptosis | 27572311 | ||
Decrease of JNK and STAT5 | Apoptosis and anti-proliferation | 30279966 | ||
PMAIP1 | Chromosome 18, NC_000018.10 (59899960..59904306) | Decrease of USP9X-MCL1 pathway | Apoptosis | 24991768 |
Activation of Beclin-1 via decrease of MCL1 | Autophagy and cell death | 21353614 | ||
Activation of the mitochondrial apoptotic pathway via interaction with BIM | Apoptosis | 26497683 | ||
XAF1 | Chromosome 17, NC_000017.11 (6755408..6775647) | Activation of Beclin-1 and decrease of Akt pathway | Apoptosis, autophagy, and cell death | 21788101 |
Decrease of VEGF | Apoptosis, anti-proliferation, and anti-angiogenesis | 24980821 | ||
IL24 | Chromosome 1, NC_000001.11 (206897404..206904139) | Activation of eIF2α phosphorylation | Apoptosis | 28461326 |
Decrease of Wnt/β-catenin signaling | Apoptosis and anti-angiogenesis | 23720015 | ||
ATF3 | Chromosome 1, NC_000001.11 (212565334..212620777) | Activation of PMAIP1 | Apoptosis | 29352505 |
Activation of Smad signaling | Cell death | 20930144 | ||
CYR61 | Chromosome 1, NC_000001.11 (85580761..85583967) | Activation of integrin α6-ROS-p38 pathway via activation of p53 | Anti-proliferation | 26028023 |
Decrease of MMP-2 | Anti-cell motility and anti-invasion | 19632997 | ||
DLC1 | Chromosome 8, NC_000008.11 (13083361..13604616, complement) | Decrease of RhoA | Anti-angiogenesis | 28408355 |
Decrease of VEGF via EGFR-MEK-HIF pathway | Anti-angiogenesis | 20861185 | ||
TNFAIP3 | Chromosome 6, NC_000006.12 (137866317..137883314) | Decrease of AKT1/TRIO/RAC1 pathway | Inhibition of EMT, anti-migration and anti-invasion | 27676292 |
Decrease of Wnt signaling via interaction with β-catenin destruction complex | Apoptosis and anti-angiogenesis | 23671587 | ||
RHOB | Chromosome 2, NC_000002.12 (20447071..20449445) | Activation of E-cadherin and decrease of Vimentin | Anti-migration and anti-invasion | 28253718 |
Decrease of NF-κB signaling | Anti-angiogenesis, anti-migration and anti-invasion | 20383180 |