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Fig. 6 | Biological Research

Fig. 6

From: TFAP2C increases cell proliferation by downregulating GADD45B and PMAIP1 in non-small cell lung cancer cells

Fig. 6

The effects of TFAP2C, GADD45B, and PMAIP1 expression levels on NSCLC cell motility. a The effects of TFAP2C overexpression, GADD45B knockdown, or PMAIP1 knockdown on cell motility of WI-26 VA4 cells were measured by using wound-healing assays. Representative images of each group are presented. b The graphs show the percentage of the available area covered by WI-26 VA4 cells from five randomly selected images. Representative images of each group at different times are presented. *p < 0.05 compared to cells treated with control vector or control siRNA. c The effects of TFAP2C overexpression, GADD45B knockdown, or PMAIP1 knockdown on cell migration capacity of WI-26 VA4 cells were measured by using transwell cell migration assays. *p < 0.05 compared to cells treated with control vector or control siRNA. d The effects of TFAP2C, GADD45B, and/or PMAIP1 knockdown on cell motility of NCI-H292, NCI-H358, NCI-H460, or A549 cells were measured by using wound-healing assays. Representative images of each group are presented. e The graphs show the percentage of the available area covered by four NSCLC cell lines from five randomly selected images. *p < 0.05 compared to cells treated with control siRNA, **p < 0.05 compared to cells treated with TFAP2C siRNA. f The effects of TFAP2C, GADD45B, and/or PMAIP1 knockdown on cell migration capacity of NCI-H292, NCI-H358, NCI-H460, or A549 cells were measured by using transwell cell migration assays. *p < 0.05 compared to cells treated with control siRNA, **p < 0.05 compared to cells treated with TFAP2C siRNA

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