Fig. 3

TFAP2C induces GADD45B and PMAIP1 downregulation in NSCLC cells. a The mRNA expression levels of GADD45B and PMAIP1 in TFAP2C-overexpressing WI-26 VA4 cells were examined by qRT-PCR. *p < 0.05 compared to non-treated cells or cells treated with control vector. b–e The mRNA expression levels of GADD45B and PMAIP1 in TFAP2C siRNA-treated NCI-H292 (b), NCI-H358 (c), NCI-H460 (d), and A549 (e) cells were examined by qRT-PCR. *p < 0.05 compared to non-treated cells or cells treated with control siRNA. f The protein expression levels of GADD45B and PMAIP1 in TFAP2C-overexpressing WI-26 VA4 cells were examined by Western blotting. g The protein expression levels of GADD45B and PMAIP1 in TFAP2C siRNA-treated NCI-H292, NCI-H358, NCI-H460, and A549 cells were examined by Western blotting