Fig. 3

CK2 inhibition decreased IR induced IL-8 and IL-6 secretion. a HUVECs was exposed to 4 Gy IR. Conditioned medium was collected 24 h after radiation. Then the concentration of IL-8, IL-1β, IL-6, IL-10, TNF-α, IL-12p70 were detected using a CBA kit. Mean ± SD were calculated for three independent experiments (***p < 0.001). HUVECs were pretreated with complete medium, DMSO, 25 μM Quinalizarin or 10 μM CX-4945 for 6 h, then exposed to 4 Gy IR. Conditioned medium was collected 24 h after radiation. Concentration of b IL-8 and c IL-6 were detected using a CBA kit. Mean ± SD were calculated for three independent experiments (***p < 0.001)