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Fig. 2 | Biological Research

Fig. 2

From: PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer

Fig. 2

Knockdown of PELI3 inhibits proliferation, migration and invasion of NSCLC cell lines. a, b Knockdown efficiency of PELI3 in A549 and H1299 cells transfected with PELI3 siRNA (si-PELI3-1 and si-PELI3-2) or negative control siRNA (si-NC) was confirmed by qRT-PCR and western blot. c, d Colony formation and MTT assays showed knockdown of PELI3 significantly suppressed proliferation of A549 and H1299 cells. e Wound-healing assays showed the repression of cell migration of A549 and H1299 due to knockdown of PELI3. f Transwell assays showed the repression of cell invasion of A549 and H1299 due to knockdown of PELI3. The data represent the mean ± SD from three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 (two-way ANOVA for d, student’s t-test for others)

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