Fig. 6From: Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathwaysProposed model by which HBV induced liver fibrosis through Wnt 5a mediated NFAT and Jnk pathway. HBV infection enhanced Wnt 5a production and secretion by hepatocyte, which in turn activated HSC by regulating NFAT and Jnk pathway. Notum can deacylate Wnt 5a protein, and subsequently inhibit NFATc1 and Jnk mediated HSC activation and liver fibrosisBack to article page