Fig. 4
From: MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1
MIR-382 directly target SP1 in CRC. a The predicted MIR-382 binding site within Sp2 3′-UTR and its mutated version. b MIR-382 mimic inhibited the expression of SP1 in HT29 cells. c MIR-382 mimic inhibited luciferase activity of cells transfected with pMIR-SP1-3′-UTR Wt but not pMIR-SP1-3′-UTR Mut. d Correlation between MIR-382 and SP1 expression in CRC tissues. (***P < 0.001, ns: not significant) MIR-382: microRNA-382; NC: negative control; SP1: specific protein 1; Wt: wild-type; mut: mutant; CRC: colorectal cancer; UTR: untranslated region