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Fig. 3 | Biological Research

Fig. 3

From: MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2

Fig. 3

HMGA2 is a functional target of miR-219-5p in SKOV3 cells. a miR-219-5p and its predicted binding sequence in WT (wild-type) HMGA2. b MiR-219-5p suppresses the luciferase reporter activity of wild-type but has no significant impact on mutant HMGA2. Data are expressed as mean ± SD, n = 5. ***P < 0.001 versus other groups. c qRT-PCR showing that miR-219-5p overexpression triggers significant suppression of HMGA2 mRNA. Data are expressed as mean ± SD, n = 5. ***P < 0.001 versus control. d Transfection of miR-219-5p decreases tumor growth. Data are expressed as mean ± SD, n = 6. *P < 0.05, ***P < 0.001 versus control. e Images of tumor tissues from different groups on day 25. f, g Western blot and RT-PCR analyses showing that miR-219-5p overexpression triggers a significant decrease in HMGA2 protein and mRNA levels, respectively. Data are expressed as mean ± SD, n = 5. ***P < 0.001 versus control

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