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Fig. 2 | Biological Research

Fig. 2

From: MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2

Fig. 2

HMGA2 overexpression suppresses miR-219-5p-induced cell proliferation, migration and invasion. a Western blot showing HMGA2 expression in SKOV3 cells after treatment with scramble, miR-219-5p mimic or HMGA2 (transfected with HMGA2 overexpression vector). b Overexpression of HMGA2 significantly reverses miR-219-5p-induced suppression of SKOV3 cell proliferation. Data are expressed as mean ± SD, n = 5. *P < 0.05, ***P < 0.001 versus scramble. #P < 0.05, ###P < 0.001 versus the mimic group. c, d Cell migration and invasion of SKOV3 determined using the Transwell® assay. Data are expressed as mean ± SD, n = 5. *P < 0.05, ***P < 0.001 versus scramble. ###P < 0.001 versus the mimic group

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