Fig. 3
From: Thiamine deficiency contributes to synapse and neural circuit defects
Thiamine deficiency induced spine density decrease in vivo. a Representative images of spines from hippocampal CA1 and cortex S1 regions of control mice and thiamine deficiency mice. Scale bars represent 5 µm. b Quantitation of spine density in CA1 and S1 L2/3 pyramidal neurons. Spine density in thiamine deficiency mice was significantly reduced as compared with that in control mice (N = 3 and 4 mice, n = 22, 26 cells numbers, P < 0.001 (CA1), and 30, 40 cells numbers, P < 0.05 (S1). All the data are expressed as mean ± SEM from three or four independent experiments. *P < 0.05, ***P < 0.0001, student’s t test and one-way ANOVA were used to determine the statistical significance of the differences