Table 3 The enriched pathways for the nodes in module 1 and 3
Pathway name | Count | p-value | Genes |
|---|---|---|---|
Module 1 | |||
hsa04080:neuroactive ligand–receptor interaction | 11 | 7.94E−12 | P2RY6, GRM2, OPRL1, P2RY14, CHRM1, GRM7, ADRA2A, ADRA1B, ADRA1A, GRM1, HTR2A |
hsa04020:calcium signaling pathway | 6 | 1.83E−05 | ADCY2, CHRM1, ADRA1B, ADRA1A, GRM1, HTR2A |
hsa04724:glutamatergic synapse | 4 | 1.39E−03 | ADCY2, GRM2, GRM7, GRM1 |
hsa04022:cGMP-PKG signaling pathway | 4 | 4.08E−03 | ADCY2, ADRA2A, ADRA1B, ADRA1A |
hsa04970:salivary secretion | 3 | 1.26E−02 | ADCY2, ADRA1B, ADRA1A |
hsa04540:gap junction | 3 | 1.32E−02 | ADCY2, GRM1, HTR2A |
hsa04270:vascular smooth muscle contraction | 3 | 2.34E−02 | ADCY2, ADRA1B, ADRA1A |
hsa04261:adrenergic signaling in cardiomyocytes | 3 | 3.42E−02 | ADCY2, ADRA1B, ADRA1A |
Module 3 | |||
hsa04724:glutamatergic synapse | 5 | 2.37E−06 | SLC17A7, DLGAP1, GRIN1, GRIN3A, SHANK2 |
hsa05033:nicotine addiction | 3 | 6.74E−04 | SLC17A7, GRIN1, GRIN3A |
hsa04024:cAMP signaling pathway | 3 | 1.56E−02 | GRIN1, GHRL, GRIN3A |
hsa05030:cocaine addiction | 2 | 4.86E−02 | GRIN1, GRIN3A |