Table 1 The significantly enriched GO terms associated with pain in goats
Go term | Count | P value | Gene |
|---|---|---|---|
Up-regulated | |||
 GO:0006811 ~ ion transport | 33 | 1.69E−04 | SCN3A, SLC38A8, GABRB1, GRIK3, CNGB1, SLCO1A2, GRID2, SLC4A4, KCNG3, CHRNA1, CLCA1, GABRA4, TRPC5, SLC12A3, GRIN2A, SLC22A20, KCNK1, CACNA2D4, ITPR2, SLCO1B3, GRIA2, SLC17A4, SLC26A7, CACNA1E, KCNH8, ATP7B, KCNH5 |
 GO:0022836 ~ gated channel activity | 18 | 3.76E−04 | GABRA4, SCN3A, TRPC5, GABRB1, GRIK3, GRIN2A, CNGB1, KCNK1, ITPR2, CACNA2D4, GRIA2, GRID2, KCNH8, CACNA1E, KCNG3, CHRNA1, FGF2, KCNH5 |
 GO:0022834 ~ ligand-gated channel activity | 11 | 3.98E−04 | GRIA2, GABRA4, TRPC5, GABRB1, GRIK3, GRID2, GRIN2A, CNGB1, CHRNA1, KCNK1, ITPR2 |
 GO:0005216 ~ ion channel activity | 20 | 6.64E−04 | CLCA1, GABRA4, SCN3A, TRPC5, GRIK3, GABRB1, GRIN2A, CNGB1, KCNK1, ITPR2, CACNA2D4, GRIA2, SLC26A7, GRID2, KCNH8, CACNA1E, KCNG3, CHRNA1, FGF2, KCNH5 |
 GO:0022832 ~ voltage-gated channel activity | 9 | 0.058679 | SCN3A, GRIN2A, CACNA1E, KCNH8, KCNG3, KCNK1, FGF2, KCNH5, CACNA2D4 |
 GO:0008066 ~ glutamate receptor activity | 5 | 0.004105 | GRM3, GRIA2, GRIK3, GRID2, GRIN2A |
 IPR001508:NMDA receptor | 4 | 0.005749 | GRIA2, GRIK3, GRID2, GRIN2A |
 GO:0006816 ~ calcium ion transport | 8 | 0.03123 | CLCA1, NPY, TRPC5, GRIN2A, CACNA1E, JPH1, ITPR2, CACNA2D4 |
 GO:0006955 ~ immune response | 18 | 0.291463 | CXCL1, PSMB10, AQP9, S100A7, C6, CXCL9, CD180, PDCD1LG2, CCL27, TNFSF8, APOA4, C8A, CD96, OASL, CFHR5, VSIG4, IL1RAPL1, IFI6 |
 GO:0009611 ~ response to wounding | 13 | 0.432142 | CXCL1, SELP, C6, MAP1B, CXCL9, GRIN2A, CD180, C8A, FGA, SERPINB2, VSIG4, CFHR5, FGF2 |
 GO:0006954 ~ inflammatory response | 8 | 0.526807 | C8A, CXCL1, SELP, C6, CXCL9, CFHR5, VSIG4, CD180 |
 GO:0006952 ~ defense response | 14 | 0.540829 | CXCL1, SELP, S100A7, C6, CXCL9, FOXN1, VARS, CD180, CLEC1A, APOA4, C8A, VSIG4, CFHR5, IL1RAPL1 |
Down-regulated | |||
 IPR001073:Complement C1q protein | 8 | 5.07E−04 | CBLN4, C1QTNF3, C1QTNF1, C1QTNF2, EMILIN2, MMRN1, ADIPOQ, COL8A2 |
 GO:0009611 ~ response to wounding | 46 | 8.77E−05 | GGCX, ERBB3, F13A1, TGFB3, AFAP1L2, MMRN1, SRF, TIMP3, SHH, AZU1, CCL24, IGSF10, S1PR3, HRH1, CASP3, CCL21, LTB4R, LOX, THBS1, FN1, RAB27A, INA, KLF6, CR2, LIPA, GATM, CYP1A1, PDPN, SAAL1, ANXA1, CHST3, COL5A1, NOTCH3, TNFAIP6, SDC1, LYVE1, THBD, TFRC, ADM, SERPINF2, ITGA5, PDGFRA, HBEGF, VCAN, IGFBP4, AOC3 |
 GO:0006954 ~ inflammatory response | 19 | 0.270975 | LIPA, CR2, PDPN, SAAL1, ANXA1, AFAP1L2, CCL24, AZU1, S1PR3, TNFAIP6, HRH1, TFRC, LTB4R, CCL21, SERPINF2, THBS1, IGFBP4, AOC3, FN1 |
 GO:0006952 ~ defense response | 25 | 0.855432 | AFAP1L2, CCL24, AZU1, S1PR3, HRH1, LTB4R, CCL21, THBS1, FN1, RAB27A, CR2, LIPA, PDPN, SAAL1, ANXA1, COLEC12, INHBB, TNFAIP6, INHBA, BPI, TFRC, SERPINF2, IGFBP4, ICOSLG, AOC3 |
 GO:0045202 ~ synapse | 27 | 0.015927 | CDK5R1, SNCAIP, SYT4, ERBB3, SYT6, SV2B, PRKACA, SV2A, APBA1, GABRG2, EFNB1, SYT11, RIMBP2, SYT12, NLGN1, LIN7C, PPP1CC, RPH3A, SSPN, CBLN4, EGFLAM, COLQ, MAP1S, GRM8, CHRNB3, VAMP3, DOC2B |
 GO:0044456 ~ synapse part | 16 | 0.180734 | GABRG2, SNCAIP, SYT4, ERBB3, SYT11, NLGN1, LIN7C, SYT6, RPH3A, SSPN, GRM8, CHRNB3, SV2B, SV2A, DOC2B, APBA1 |
 GO:0045596 ~ negative regulation of cell differentiation | 19 | 0.01342 | TWSG1, SIX2, SOCS5, JAG1, LIG4, GLI2, SOX9, ADIPOQ, SHH, HES1, NOTCH3, INHBA, RNF6, HOXA2, RHOA, TGFBR3, TOB2, BMPR1A, TOB1 |
 IPR001565:Synaptotagmin | 5 | 0.005111 | SYT4, SYT11, SYT6, RPH3A, DOC2B |
 GO:0005544 ~ calcium-dependent phospholipid binding | 4 | 0.115606 | SYT11, ANXA1, DOC2B, RBM12 |
 GO:0045664 ~ regulation of neuron differentiation | 12 | 0.048765 | NOTCH3, AMIGO1, HES1, HOXA2, CDK5R1, RNF6, NLGN1, RHOA, SEMA4D, GLI2, SHH, KALRN |