Fig. 4

CMPD1 induced G2/M cell cycle arrest in MKN-45 cells. a Human gastric cancer cell line MKN-45 cells were treated with 0, 0.1, 0.3, and 1.0 μM of CMPD1 respectively for 24 h, and cell cycle distribution of MKN-45 was analyzed by flow cytometry. b The proportion of cells in G1, S, G2/M phase was exhibited from three independent experiments. CMPD1 significantly arrested cell cycle at G2/M phase in a dose-dependent manner. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. control