Fig. 8

Effect of loss of PPARα on lipopolysaccharide (LPS)-induced liver injury and cytokine response. Wild type and PPARα^−/− mice were administered LPS by intraperitoneal injection 6 h prior to sacrifice. a Representative photomicrographs of liver sections from wild type or PPARα^−/− mice shown at ×400 magnification. b Serum alanine aminotransferase (ALT) levels 6 h following LPS exposure. c Serum IL12 and d serum IFNγ protein levels 6 h following LPS exposure as assessed by ELISA. *p < 0.05 vs. respective vehicle treated control. ⁺p<0.05 vs. LPS-treated wild type mouse