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Fig. 7 | Biological Research

Fig. 7

From: Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice

Fig. 7

Reconstitution of severe combined immunodeficient (SCID) mice with wild type or PPARα−/− splenocytes reconstitutes ConA mediated liver injury. a Immunohistochemical assessment of CD3+ cells within the spleens and livers of wild type and SCID mice as well as SCID mice reconstituted with either wild type or PPARα−/− splenocytes. b Hematoxylin and Eosin stained or terminal UTP nick end labeled (TUNEL) stained sections from wild type and SCID mice as well as SCID mice reconstituted with either wild type or PPARα−/− splenocytes 10 h following treatment with ConA (15 mg/kg). Representative ×100 photomicrographs presented. c Serum alanine aminotransferase (ALT) levels in wild type or SCID mice or SCID mice reconstituted with either wild type or PPARα−/− splenocytes 10 h after intravenous treatment with 15 mg/kg ConA. d IL4 and IFNγ message expression in wild type or SCID mice or SCID mice reconstituted with either wild type or PPARα−/− splenocytes 10 h after intravenous treatment with 15 mg/kg ConA. n = 4 animals per group

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