Fig. 1
a Protein arrangement showing how the two regions of helical domains interact to form the three dimensional structure of the protein. Pore of the AQP is composed of two halves called as hemipores. MIPs consist of six transmembrane domains connected by five loops (A–E), with cytoplasmic N- and C-termini. Locations of NPA (Asn-Pro-Ala) motifs are at the loops B and E. b Functional AQP formed by the interaction of the two hemipores [30, 31]