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Table 3 Mutations present in more than one cohort

From: Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Country Mutation Exon Hereditary BC Early-onset BC Unselected BC
BRCA1
 Brazil c.5266dupC 20 a a a
 Brazil c.560+2T>A 7  
 Brazil c.3331_3334delCAAG 11  
 Brazil c.5251C>T 20  
 Colombia c.3331_3334delCAAG 11 a  a
 Colombia c.5123C>A 18 a  a
 Mexico c.548?_4185?del 9_12  
 Mexico c.4065_4068delTCAA 11  
 Mexico c.2296-2297delAG 11  
 Mexico c.2433delC 11
 Mexico c.3598C>T 11  
 Mexico c.4327C>T 13  
 Mexico c.5123C>A 18
 Mexico c.211 A>G 5  
 Mexico c.3759_3760delTA 11  
BRCA2
 Brazil c.2808_2811delACAA 11  
 Colombia c.2808_2811delACAA 11 a  a
 Mexico c.2808_2811delACAA 11  
 Mexico c.1796-1800delTTTAT 10  a
 Mexico c.4111C>T 11  
  1. BC breast cancer
  2. ✔ = Mutation present
  3. aRecurrent mutation