Fig. 5

The p38 MAPK signaling pathway was involved in TMPyP4-triggered cell apoptosis in human cervical cancer cells. Cells were treated with SB203580 for 24 h, and 20 μM TMPyP4 was added for 24 h, then cell apoptotic rates (a), caspase-3 activity (b), PARP and caspase-3 protein expression (c) were measured. Data are expressed as mean ± SD of three independent experiments in six replicates. *P < 0.05 or **P < 0.01 indicates significance, P > 0.05 means no difference