Types | Models | Parameters | Realgar | NPSf | ATO | RBS | Reference |
---|---|---|---|---|---|---|---|
Cell lines | HepG2 | IC50 in 72 h (μg/ml) | NDa | NDa | 0.58 ± 0.08 | 0.43 ± 0.06 | |
H22 | Apoptotic rateb (%) | NDa | NDa | 12.8 | 15.8 | ||
H22 | IC50 at 72 h (µM) | 104.36 | 34.27 | NDa | NDa | [27] | |
H22 | AUC0→24 (ng h/l) | 1282.28 ± 586.23 | 4796.25 ± 479.885 | NDa | NDa | [27] | |
H22 | t½ (h) | 44.9 ± 18.1 | 53.3 ± 44.9 | NDa | NDa | [27] | |
H22 | Biodistributionc (ng/g) | 320 | 610 | NDa | NDa | [27] | |
SiHa cells | Toxicity (g/kg) | 3.2 | NDa | 0.033–0.039 | NDa | ||
SiHa cells | Bioavailability rate (%) | 4% | NDa | High | NDa | ||
C6 | Apoptotic rate (%) | 4.73% ± 0.46 | 26.02 ± 0.28 | ND | NDa | [31] | |
HeLa | IC50 at 72 h (µM) | 8.69 ± 2.57 | NDa | 1.85 ± 0.54 | NDa | [94] | |
ECV-304 | Toxic | More | Less | NDa | NDa | [32] | |
ECV-304 | Bioavailability | Low | High | NDa | NDa | [32] | |
B16 | Apoptotic rate (%) | NDa | 11.4–54.95 | ND.a | ND.a | [29] | |
B16 | Inhibitory rated (%) | NDa | NDa | 22.70 | 27.0 | [78] | |
B16 | Accumulating rate (%) | ND.a | NDa | 36.6 | 71.50 | [78] | |
B16 | t½ (h) | 8.09 ± 2.27 | 10.13 ± 3.19 | NDa | NDa | [1] | |
C. elegans | MT2124 | LC50 (μg/mg) | ND | NDa | 55 | 81 | [76] |
S180-bearing | Inhibition rate (%) | 39.5 | 53.14 | NDa | NDa | [1] | |
H22-bearing | Inhibitory rate (%) | NDa | NDa | 41.87 | 42.78 | ||
Mice | H22-bearing | Extending ratese (%) | NDa | NDa | 91.96 | 118.80 | |
Healthy mice | LD50 (g/kg) | 3.2 | NDa | 0.033–0.039 | NDa | [4] | |
Healthy mice | Bioavailability rate (%) | 4% | NDa | NDa | NDa | [4] |