Skip to main content

Table 1 The comparison of pharmacological activities among different arsenic agent in vivo and in vitro

From: Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Types

Models

Parameters

Realgar

NPSf

ATO

RBS

Reference

Cell lines

HepG2

IC50 in 72 h (μg/ml)

NDa

NDa

0.58 ± 0.08

0.43 ± 0.06

[10, 77]

H22

Apoptotic rateb (%)

NDa

NDa

12.8

15.8

[10, 77]

H22

IC50 at 72 h (µM)

104.36

34.27

NDa

NDa

[27]

H22

AUC0→24 (ng h/l)

1282.28 ± 586.23

4796.25 ± 479.885

NDa

NDa

[27]

H22

t½ (h)

44.9 ± 18.1

53.3 ± 44.9

NDa

NDa

[27]

H22

Biodistributionc (ng/g)

320

610

NDa

NDa

[27]

SiHa cells

Toxicity (g/kg)

3.2

NDa

0.033–0.039

NDa

[3, 30]

SiHa cells

Bioavailability rate (%)

4%

NDa

High

NDa

[3, 30]

C6

Apoptotic rate (%)

4.73% ± 0.46

26.02 ± 0.28

ND

NDa

[31]

HeLa

IC50 at 72 h (µM)

8.69 ± 2.57

NDa

1.85 ± 0.54

NDa

[94]

ECV-304

Toxic

More

Less

NDa

NDa

[32]

ECV-304

Bioavailability

Low

High

NDa

NDa

[32]

B16

Apoptotic rate (%)

NDa

11.4–54.95

ND.a

ND.a

[29]

B16

Inhibitory rated (%)

NDa

NDa

22.70

27.0

[78]

B16

Accumulating rate (%)

ND.a

NDa

36.6

71.50

[78]

B16

t½ (h)

8.09 ± 2.27

10.13 ± 3.19

NDa

NDa

[1]

C. elegans

MT2124

LC50 (μg/mg)

ND

NDa

55

81

[76]

S180-bearing

Inhibition rate (%)

39.5

53.14

NDa

NDa

[1]

H22-bearing

Inhibitory rate (%)

NDa

NDa

41.87

42.78

[10, 77]

Mice

H22-bearing

Extending ratese (%)

NDa

NDa

91.96

118.80

[10, 77]

Healthy mice

LD50 (g/kg)

3.2

NDa

0.033–0.039

NDa

[4]

Healthy mice

Bioavailability rate (%)

4%

NDa

NDa

NDa

[4]

  1. ND no data
  2. aThe figures is not given in the paper
  3. bThe percentage of the apoptotic cells
  4. cThe arsenic accumulation in tumor
  5. dThe cancer cells growth inhibitory rate
  6. eThe mice life extending rate
  7. fRealgar nanometer particles