Skip to main content

Table 1 The comparison of pharmacological activities among different arsenic agent in vivo and in vitro

From: Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Types Models Parameters Realgar NPSf ATO RBS Reference
Cell lines HepG2 IC50 in 72 h (μg/ml) NDa NDa 0.58 ± 0.08 0.43 ± 0.06 [10, 77]
H22 Apoptotic rateb (%) NDa NDa 12.8 15.8 [10, 77]
H22 IC50 at 72 h (µM) 104.36 34.27 NDa NDa [27]
H22 AUC0→24 (ng h/l) 1282.28 ± 586.23 4796.25 ± 479.885 NDa NDa [27]
H22 t½ (h) 44.9 ± 18.1 53.3 ± 44.9 NDa NDa [27]
H22 Biodistributionc (ng/g) 320 610 NDa NDa [27]
SiHa cells Toxicity (g/kg) 3.2 NDa 0.033–0.039 NDa [3, 30]
SiHa cells Bioavailability rate (%) 4% NDa High NDa [3, 30]
C6 Apoptotic rate (%) 4.73% ± 0.46 26.02 ± 0.28 ND NDa [31]
HeLa IC50 at 72 h (µM) 8.69 ± 2.57 NDa 1.85 ± 0.54 NDa [94]
ECV-304 Toxic More Less NDa NDa [32]
ECV-304 Bioavailability Low High NDa NDa [32]
B16 Apoptotic rate (%) NDa 11.4–54.95 ND.a ND.a [29]
B16 Inhibitory rated (%) NDa NDa 22.70 27.0 [78]
B16 Accumulating rate (%) ND.a NDa 36.6 71.50 [78]
B16 t½ (h) 8.09 ± 2.27 10.13 ± 3.19 NDa NDa [1]
C. elegans MT2124 LC50 (μg/mg) ND NDa 55 81 [76]
S180-bearing Inhibition rate (%) 39.5 53.14 NDa NDa [1]
H22-bearing Inhibitory rate (%) NDa NDa 41.87 42.78 [10, 77]
Mice H22-bearing Extending ratese (%) NDa NDa 91.96 118.80 [10, 77]
Healthy mice LD50 (g/kg) 3.2 NDa 0.033–0.039 NDa [4]
Healthy mice Bioavailability rate (%) 4% NDa NDa NDa [4]
  1. ND no data
  2. aThe figures is not given in the paper
  3. bThe percentage of the apoptotic cells
  4. cThe arsenic accumulation in tumor
  5. dThe cancer cells growth inhibitory rate
  6. eThe mice life extending rate
  7. fRealgar nanometer particles