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Fig. 1 | Biological Research

Fig. 1

From: BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis

Fig. 1

BJ-1108 inhibits CD4+ T cell differentiation. a Naïve CD4+ T cells isolated from spleens and draining lymph nodes were stimulated under Th1- and Th17-polarizing conditions in the presence or absence of 10 μM BJ-1108 for 72 h. Cells were then re-stimulated with phorbol 12-myristate 13-acetate, ionomycin, and GolgiStop for 4 h, followed by intracellular cytokine staining and flow cytometry. b Th1 and Th17 differentiation with multiple concentrations of BJ-1108. Representative data (mean ± SEM) of three independent experiments are shown. **p < 0.001 and ***p < 0.0001 versus vehicle

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