Table 1 The enriched gene ontology terms and pathways of the differentially expressed genes (DEGs) in carcinoma-associated fibroblasts (CAF) of non-small cell lung carcinoma (NSCLC)
Category | Term | Count | p value |
|---|---|---|---|
Up-regulated genes | |||
 BP | GO:0007166~cell surface receptor linked signal transduction | 16 | 4.95E−04 |
GO:0007186~G-protein coupled receptor protein signaling pathway | 12 | 7.29E−04 | |
GO:0008544~epidermis development | 5 | 0.0029 | |
GO:0030335~positive regulation of cell migration | 4 | 0.0030 | |
GO:0007398~ectoderm development | 5 | 0.0039 | |
GO:0040017~positive regulation of locomotion | 4 | 0.0039 | |
GO:0051272~positive regulation of cell motion | 4 | 0.0039 | |
 CC | GO:0005576~extracellular region | 13 | 0.0249 |
GO:0005886~plasma membrane | 19 | 0.0456 | |
 MF | GO:0005179~hormone activity | 3 | 0.0496 |
Down-regulated genes | |||
 BP | GO:0007416~synaptogenesis | 9 | 1.31E−06 |
GO:0016339~calcium-dependent cell–cell adhesion | 8 | 1.43E−06 | |
GO:0043062~extracellular structure organization | 16 | 2.72E−05 | |
GO:0016485~protein processing | 12 | 1.80E−04 | |
GO:0050808~synapse organization | 9 | 1.89E−04 | |
GO:0030324~lung development | 11 | 2.80E−04 | |
GO:0030323~respiratory tube development | 11 | 3.57E−04 | |
 CC | GO:0005576~extracellular region | 87 | 2.38E−06 |
GO:0044421~extracellular region part | 45 | 2.47E−04 | |
GO:0005624~membrane fraction | 38 | 8.21E−04 | |
 MF | GO:0005509~calcium ion binding | 47 | 2.44E−05 |
GO:0015923~mannosidase activity | 4 | 0.0067 | |
GO:0019838~growth factor binding | 9 | 0.0070 | |