50 years of amino acid hydrophobicity scales: revisiting the capacity for peptide classification

Biological Research

Table 2 Sequence pools based in silico K/R-digestion

Abbr.	Sequences		Description
dc-helix	8208	Dominating SSE	α-helix; continuous
dc-sheet	1978		β-sheet; continuous
dc-random	4490		random coil; continuous
dd-helix	5154		α-helix; discontinuous
dd-sheet	3322		β-sheet; discontinuous
dd-random	2331		random coil; discontinuous
no-helix	11039	No dominating SSE	β-sheets and random coils
no-sheet	7770		α-helices and random coils
no-random	281		β-sheets and α-helices
all	22237		β-sheets, a-helices, and random coils
krtm-helix	214		TM α-helices with additional AA at N- or C-terminus
krtm-sheet	119		TM β-sheets with additional AA at N- or C-terminus

All peptides have a minimal length of ten amino acids (AA). Dominating SSE stands for SSE content larger than 70 % of all AA. Continuous means that this SSE is without gap
TM transmembrane. The nomenclature is as follows: dc peptide derived by in silico tryptic digest with continuous structural element, dd peptide derived by in silico tryptic digest with discontinuous structural element, krtm peptide derived by in silico tryptic digest (kr) with transmembrane segment

ISSN: 0717-6287