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Fig. 2 | Biological Research

Fig. 2

From: The anti-cancerous activity of recombinant trichosanthin on prostate cancer cell PC3

Fig. 2

rTCS inhibits proliferation and induces apoptosis of PC3 cells. a A series of concentration of rTCS including 10, 20, 40, 60, 80, 120 ug/ml was used to treat PC3 cells. And rTCS was shown to inhibit proliferation of PC3 cells in a dose-dependent manner. b 50 µg/ml rTCS was combined with 2 μM IL-2 to treat PC3 cells. The inhibitory rate in combinatory group was about 50 % while it was only 35.5 % in 50 µg/ml rTCS single group. c rTCS activates caspase-8-mediated apoptosis. The level of full length caspase-8 and Bcl-2 decreased significantly in 20 or 60 µg/ml rTCS-treated group after 24 h. But the level of cleaved caspase-8 as well as Bax dramatically increased. Statistical analysis of data was performed with t-test, and *P<0.05 indicated a statistically significant difference

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