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Table 2 Results of anti-angiogenic assay of various samples of Rumex hastatus

From: Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.

Samples Conc. 31. 25 µg/ml Conc. 62.5 µg/ml Conc. 125 µg/ml Conc. 250 µg/ml Conc. 500 µg/ml Conc. 1000 µg/ml IC50 µg/ml
Rh.Cr 39. 3 ± 0.7*** 43.5 ± 0.6*** 48.7 ± 0.8*** 54.1 ± 0.2*** 62.4 ± 0.3*** 71.3 ± 1.3*** 164.3
Rh.Hex 27.3 ± 1.3*** 32.9 ± 0.5*** 36.7 ± 0.8*** 41.9 ± 0.3*** 43.0 ± 0.2*** 47.2 ± 1.1*** 1011.5
Rh.Chf 56.7 ± 1.6* 59.3 ± 0.6** 64.7 ± 1.6 68.3 ± 0.5* 74.3 ± 1.2* 81.6 ± 1.7* 17.9
Rh.EtAc 43.3 ± 0.6*** 49.6 ± 0.8** 55.3 ± 0.3** 61.0 ± 1.2*** 67.3 ± 0.7*** 72.3 ± 1.2*** 65.5
Rh.Aq 11.6 ± 1.7 16.0 ± 1.1 23.3 ± 1.2 33.3 ± 0.3 37.0 ± 1.6 46.3 ± 0.4 1034.2
Rh.Sp 43.4 ± 0.9*** 49.1 ± 1.4** 54.0 ± 0.6** 67.9 ± 0.5** 71.4 ± 0.3*** 78.9 ± 1.0** 64.9
  1. Dexamethasone was used as positive control with IC50 value of 11.68 µg/ml; data is represented as mean ± SEM (Standard Error Mean); * <0.05, ** <0.01, *** <0.001
  2. Rh.Cr crude methanolic extract, Rh.Hex n-hexane fraction, Rh.Chf chloroform fraction, Rh.EtAc ethyl acetate fraction, Rh.Aq aqueous fraction, Rh.Sp saponins