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Table 2 Results of anti-angiogenic assay of various samples of Rumex hastatus

From: Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.

Samples

Conc. 31. 25 µg/ml

Conc. 62.5 µg/ml

Conc. 125 µg/ml

Conc. 250 µg/ml

Conc. 500 µg/ml

Conc. 1000 µg/ml

IC50 µg/ml

Rh.Cr

39. 3 ± 0.7***

43.5 ± 0.6***

48.7 ± 0.8***

54.1 ± 0.2***

62.4 ± 0.3***

71.3 ± 1.3***

164.3

Rh.Hex

27.3 ± 1.3***

32.9 ± 0.5***

36.7 ± 0.8***

41.9 ± 0.3***

43.0 ± 0.2***

47.2 ± 1.1***

1011.5

Rh.Chf

56.7 ± 1.6*

59.3 ± 0.6**

64.7 ± 1.6

68.3 ± 0.5*

74.3 ± 1.2*

81.6 ± 1.7*

17.9

Rh.EtAc

43.3 ± 0.6***

49.6 ± 0.8**

55.3 ± 0.3**

61.0 ± 1.2***

67.3 ± 0.7***

72.3 ± 1.2***

65.5

Rh.Aq

11.6 ± 1.7

16.0 ± 1.1

23.3 ± 1.2

33.3 ± 0.3

37.0 ± 1.6

46.3 ± 0.4

1034.2

Rh.Sp

43.4 ± 0.9***

49.1 ± 1.4**

54.0 ± 0.6**

67.9 ± 0.5**

71.4 ± 0.3***

78.9 ± 1.0**

64.9

  1. Dexamethasone was used as positive control with IC50 value of 11.68 µg/ml; data is represented as mean ± SEM (Standard Error Mean); * <0.05, ** <0.01, *** <0.001
  2. Rh.Cr crude methanolic extract, Rh.Hex n-hexane fraction, Rh.Chf chloroform fraction, Rh.EtAc ethyl acetate fraction, Rh.Aq aqueous fraction, Rh.Sp saponins