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Table 1 Anti-tumor activity of various samples of Rumex hastatus

From: Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.

Samples Concentrations (µg/ml) Average inhibition (mean ± SEM) Percent inhibition (mean ± SEM) IC50 (µg/ml)
Rh.Cr 1000 25.7 ± 0.3 85.5 ± 1.1*** 197.9
500 19.0 ± 0.6 63.3 ± 1.9***
250 16.0 ± 1.2 53.3 ± 3.8***
125 13.3 ± 0.3 44.4 ± 1.1***
62.5 12.0 ± 0.0 40.0 ± 0.0***
31.25 10.0 ± 0.6 33.3 ± 1.9***
Rh.Hex 1000 19.0 ± 0.6 63.3 ± 1.9*** 395.1
500 16.3 ± 0.3 54.4 ± 1.1***
250 12.7 ± 0.3 42.2 ± 1.1***
125 11.0 ± 1.2 36.7 ± 3.8***
62.5 10.7 ± 0.3 35.5 ± 1.1***
31.25 08.0 ± 0.0 26.7 ± 0.0***
Rh.Chf 1000 26.0 ± 1.2 86.7 ± 3.8* 31.6
500 23.3 ± 0.3 77.8 ± 1.1**
250 21.0 ± 0.0 70.0 ± 0.0***
125 19.7 ± 0.3 65.5 ± 1.1**
62.5 17.7 ± 0.7 58.9 ± 2.2***
31.25 15.0 ± 0.6 50.0 ± 1.9***
Rh.EtAc 1000 24.0 ± 0.6 80.0 ± 1.9** 62.5
500 19.7 ± 0.7 65.5 ± 2.2***
250 18.0 ± 0.6 60.0 ± 1.9***
125 16.0 ± 1.2 53.3 ± 3.8***
62.5 15.0 ± 0.0 50.0 ± 0.0***
31.25 13.0 ± 1.2 43.3 ± 3.8***
Rh.Aq 1000 14.0 ± 0.0 46.7 ± 0.0*** 1138.9
500 12.6 ± 0.3 42.2 ± 1.1***
250 11.6 ± 0.3 38.9 ± 1.1***
125 09.0 ± 0.6 30.0 ± 1.9***
62.5 08.7 ± 0.3 28.9 ± 1.1***
31.25 05.3 ± 0.3 17.8 ± 1.1***
Rh.Sp 1000 28.0 ± 0.0 93.3 ± 0.0ns 18.1
500 25.0 ± 0.6 83.3 ± 1.9*
250 23.7 ± 0.3 78.9 ± 1.1*
125 19.0 ± 0.6 63.3 ± 1.9**
62.5 17.0 ± 1.2 56.7 ± 3.9***
31.25 16.0 ± 0.0 53.3 ± 0.0**
  1. Vincristine sulfate was used as positive control having IC50 value < 0.1 µg/ml; *<0.05, **<0.01, ***<0.001
  2. Rh.Cr crude methanolic extract, Rh.Hex n-hexane fraction, Rh.Chf chloroform fraction, Rh.EtAc ethyl acetate fraction, Rh.Aq aqueous fraction, Rh.Sp saponins
  3. ns Non-significant