TY - JOUR AU - Ahmad, Sajjad AU - Ullah, Farhat AU - Ayaz, Muhammad AU - Zeb, Anwar AU - Ullah, Farman AU - Sadiq, Abdul PY - 2016 DA - 2016/03/12 TI - Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don. JO - Biological Research SP - 18 VL - 49 IS - 1 AB - Cancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation of natural sources has been proven to be an excellent approach to treat or minify the excessive angiogenesis and proliferation of cells. Similarly, based the ethnomedicinal uses and literature survey, the current study is designed to explore the anti-tumor and anti-angiogenic potentials of Rumex hastatus. Anti-tumor and anti-angiogenic activities were carried out using potato-disc model and chorioallantoic membrane (CAM) assay respectively. Moreover, R. hastatus was also assessed for antibacterial activity against Agrobacterium tumefaciens (tumor causing bacterial strain). The positive controls used in anti-tumor, anti-angiogenic and antibacterial activities were vincristine sulphate, dexamethasone and cefotaxime respectively. SN - 0717-6287 UR - https://doi.org/10.1186/s40659-016-0079-2 DO - 10.1186/s40659-016-0079-2 ID - Ahmad2016 ER -