Table 1 Natural animal models of AD

Naked mole-rat

28–32 years

Decreased Tau phosphorylation and amyloid-β accumulation starting at 3 months of age

[38, 76]

Mouse lemur

10–15 years

Senile plaques and neurofibrillary tangles present in cortex at 9 years of age, and hippocampus at 10 years. Procedural memory is normal, but executive function is altered at 7–11 years

[79, 94]

Octodon degus

10–12 years

Amyloid-β oligomers are present at 6 months, amyloid plaques and neurofibrillary tangles starting at 6 years of age. Synaptic dysfunction occurs prior to the detection of plaques and tangles

[2, 3, 55]

Guinea pig

5–8 years

Amyloid-β deposition and Tau phosphorylation present in frontal cortex at 4 years of age

[7]