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Table 1 Natural animal models of AD

From: Genetic variants associated with neurodegenerative Alzheimer disease in natural models

Model Lifespan Neuropathology Reference
Naked mole-rat 28–32 years Decreased Tau phosphorylation and amyloid-β accumulation starting at 3 months of age [38, 76]
Mouse lemur 10–15 years Senile plaques and neurofibrillary tangles present in cortex at 9 years of age, and hippocampus at 10 years. Procedural memory is normal, but executive function is altered at 7–11 years [79, 94]
Octodon degus 10–12 years Amyloid-β oligomers are present at 6 months, amyloid plaques and neurofibrillary tangles starting at 6 years of age. Synaptic dysfunction occurs prior to the detection of plaques and tangles [2, 3, 55]
Guinea pig 5–8 years Amyloid-β deposition and Tau phosphorylation present in frontal cortex at 4 years of age [7]