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Fig. 1 | Biological Research

Fig. 1

From: Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line

Fig. 1

Differential methylation in RPRM CpG island between breast cancer and normal control samples. a Methylation intensity pre-calculated showing as a red gradient heatmap for RPRM CpG Island. At the top part of the figure; in green, shown CpG Island. In black, shown the gene body (from 153.992.097 to 154.093.568; Chromosome 2). The black arrow marks the start transcription site (TSS). The region analyzed corresponds to the CpG Island from 154.042.600 to 154.043.700 pb (length: 1.1 kb). The cases studied were ten normal breast (top) and 77 primary tumors (below). b Methylation intensity in BC was higher than normal control samples. c. Within BC group, ERα(+) group showed higher methylation intensity than ERα(−). The Mann–Whitney test was used for each analysis. The error bars indicate standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001

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