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Fig. 2 | Biological Research

Fig. 2

From: The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis

Fig. 2

Chondrocyte apoptosis assessment and the expression of CCR2 in OA chondrocytes. a MCP-1 stimulation of wild-type (normal controls) chondrocytes resulted in an increased rate in secondary necrosis. Lower left quadrant represents viable cells, the lower right quadrant are chondrocytes in an early apoptotic state, the upper right quadrant are chondrocytes in the late apoptotic state and the upper left quadrant is chondrocyte necrosis. N, unstimulated wild-type (normal controls) chondrocytes; N–M, MCP-1 stimulated wild-type (normal controls) chondrocytes; b the variance of early apoptotic state between the two subgroups was not significant and the variance in secondary necrotic rate and both was statistically significant; and c, d MCP-1 stimulation in OA chondrocytes resulted in a significant increase in the expression of CCR2. Wild-type (normal controls), unstimulated OA chondrocytes; MCP-1, MCP-1 stimulated OA chondrocytes. *P < 0.05

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