Table 2 Acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii and reference compound (galantamine)
Compounds | Concentration (µg/mL) | % AChE inhibition | IC50 (µg/mL) |
|---|---|---|---|
1 | 50 | 94.33 ± 8.15 | 19.13 ± 0.41a |
25 | 71.67 ± 6.03 | ||
12.5 | 18.00 ± 8.89 | ||
6.25 | 28.00 ± 6.56 | ||
2 | 50 | 82.67 ± 7.04 | 34.15 ± 1.66b |
25 | 67.00 ± 4.36 | ||
12.5 | 47.33 ± 2.08 | ||
6.25 | 14.00 ± 6.00 | ||
3 | 50 | 87.00 ± 8.74 | 45.69 ± 3.65c |
25 | 70.67 ± 3.50 | ||
12.5 | 31.67 ± 5.20 | ||
6.25 | 30.33 ± 3.51 | ||
Galantamine | 20 | 83.00 ± 8.89 | 8.22 ± 2.73d |
5 | 69.67 ± 4.16 | ||
2 | 57.67 ± 4.04 | ||
0.5 | 38.00 ± 1.00 |