TY - JOUR AU - Dzoyem, Jean P. AU - Tsamo, Armelle T. AU - Melong, Raduis AU - Mkounga, Pierre AU - Nkengfack, Augustin E. AU - McGaw, Lyndy J. AU - Eloff, Jacobus N. PY - 2015 DA - 2015/10/13 TI - Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae) JO - Biological Research SP - 57 VL - 48 IS - 1 AB - Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric oxide (NO) and acetylcholinesterase (AChE) inhibitory activity and the cytotoxicity of three limonoids: trichilia lactone D5 (1), rohituka 3 (2) and dregeanin DM4 (3), isolated from Trichilia welwitschii C.DC. SN - 0717-6287 UR - https://doi.org/10.1186/s40659-015-0049-0 DO - 10.1186/s40659-015-0049-0 ID - Dzoyem2015 ER -