TY - JOUR AU - Koriauli, S. AU - Natsvlishvili, N. AU - Barbakadze, T. AU - Mikeladze, D. PY - 2015 DA - 2015/10/09 TI - Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons JO - Biological Research SP - 55 VL - 48 IS - 1 AB - In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced by glial cells and has beneficial effects on the neuronal viability. However, the mechanisms of IL-10-elicited neuroprotection are not clear. SN - 0717-6287 UR - https://doi.org/10.1186/s40659-015-0048-1 DO - 10.1186/s40659-015-0048-1 ID - Koriauli2015 ER -