Fig. 2

Genomic distributions of differentially expressed genes (DEGs) and copy number variations (CNV) related to lung squamous-cell carcinoma using Circos-plots. a, b and c Represent the genomic distribution of CNV regions of 1–10 kb, 10–50 kb and >50 kb, respectively. The outermost bars in a circle labeled with numbers represent chromosomes; the second outermost circle represents DEGs (red and green indicating up-regulated and down-regulated DEGs, respectively); the first innermost circle (inward) represent copy number deletions, and the second innermost circle (outward) representing copy number duplications (a red line indicates a CNV occurring in controls, a blue line indicates a CNV occurring in cases, with the length of the line determined by the copy number)